Wyatt-Edison's main school building, built in 1887, was originally known as the Hyde Park School. Hyde Park was first settled in the 1860's and grew as a working class neighborhood serving the railroad yards on its northern boundaries. The stately lines of the school stood in stark contrast to the small salt box houses of the poor residents and evoked the hopes and aspirations of the working class residents in a time of booming hopes and pride in public education. In 1932 the school was renamed after the death of its long-time principal.

Robert Roeschlaub, Colorado's first architect, arrived in Denver in 1873. He was the only architect in Denver for many years and served as the unanimously elected president of the American Institute of Architects local chapter from their inception in 1891 until 1911. Other notable structures designed by Mr. Roeschlaub include the Trininty Methodist Church, Chamberlin Observatory, the Dora Moore School, and the Central City Opera House.

The school was designed in a modified Romanesque Revival style. It has two stories above grade plus a full basement and encloses over 39,000 square feet in the original building. The exterior of the building if primarily modular brick with red sandstone bands and decorative panels of red terra cotta, the latter in highly ornate, floral motif. The steeply pitched roof is clad with composite shingles. Windows are double-hung with hardwood sashes. Walls are generally wood lath and plaster with a wood wainscot. Doors and frames are also wood.

The original Wyatt School received an addition in 1956, consisting of a Cafeteria/ Auditorium/Gymnasium, small kitchen, a meeting room and restrooms. This addition was typical of design of its time and consisted of a one-story minimalist brick structure.

In 1988 the Wyatt School was designated a Denver Landmark after having been closed as a Denver Public School in 1981 as a result of falling attendance when busing was discontinued in Denver. In 1995, local businessman, Chuck Phillips, purchased the school with the intention of giving it back to the community as a school for forty years, while held in trust by The Phillips Family Trust.

The Edison Project received a charter from Denver Public Schools on November 21, 1996 to operate a school at the Wyatt site with extended school days of eight hours and an extended school year of 190 days.

The entire school was renovated for a school opening of September 15, 1998, including a new addition for the Primary Academy (grades K through 2) where the old annex had been built. Renovations included an emphasis on communications technology with classrooms equipped with data/phone ports, video ports and a computer network providing video and internet access while keeping the beauty and finishes of the original structure. The sweeping staircase in the Great Hall provides visual focus while serving as a location for concerts, ceremonies and special events.

In the summer of 2003, the campus grounds were completely renovated to provide students with playground areas, basketball hoops, a shaded pavilion, outdoor drinking fountain and extensive landscaping.

Additionally, one of the computer labs and 4th - 8th grade classrooms were updated to PC computers running Microsoft programs and other educational software.